General News Research — 30 May 2014

Teenage girls could be more prone to depression and anxiety disorders because they experience greater blood flow to the brain, a new study has found.

The sex hormone oestrogen drives more blood to the heads of young women compared to men – and that could explain disparities in psychiatric disorders.

Blood flow is known to be higher in adult women than men, but a study now shows it is markedly different during adolescence when teenagers are going through puberty.

Professor Theodore Satterthwaite, of the University of Pennsylvania, said: ‘In general, females have a higher prevalence of anxiety and depression and in males higher prevalence of schizophrenia.

‘The parts of the brain that saw the highest difference of blood flow were in parts of the brain associated with higher cognitive functions.’

He added the area affected was important as it involves ’emotions and regulates and controls social situations’.bigstock-depression-teen-girl-cried-lon-27260714

Professor Satterthwaite and his colleagues used MRI scans to analyse the development of brain blood flow in 922 young people aged between eight and 22 to find out when such sex changes emerge.

Previous studies have shown brain blood flow falls during adolescence. But by about the age of 15 it began to decline more rapidly in males than in females, and by late puberty it rose in females but continued to decline in the males.

The results published in Proceedings of the National Academy of Sciences suggest the gender difference may originate during puberty, and may have implications for understanding psychiatric disorders that often manifest later.

The psychiatrists added: ‘Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow have never been investigated.’

It is the first time to the researchers’ knowledge that such different patterns of development have been linked to the effects of puberty.

Prof Satterthwaite said: ‘These results may have important implications for neuropsychiatric disorders with adolescent onset and strong gender disparities such as mood disorders, anxiety disorders and schizophrenia.’

Sex differences in brain structure are well documented and are increasingly tied to developmental effects related to puberty.

In particular, several studies have found puberty in females and rising oestrogen is related to increased grey matter in structures such as the hippocampus.

Added Prof Satterthwaite: ‘The present results have potential relevance to a wide range of psychiatric disorders that often manifest following puberty and have marked sex disparities including depression, anxiety disorders and schizophrenia.’

He added that future research could test whether increased brain blood flow in girls after puberty may be linked to the greater risk for mood and anxiety disorders, and a lower risk of schizophrenia.

Boys are twice as likely to develop schizophrenia which is linked to the male sex hormone testosterone.

This article first appeared on ‘Ninemsn – Mail Online’ on 27 May 2014.


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