General News Research — 31 December 2013

New research suggests cardiac surgery follow-up care should include an assessment for depression as 40 percent of individuals suffer from depression after the procedure.

Investigators say that physical activity should also be evaluated as inactivity can increase rates of depression. Post-op depression can increase the risk of additional cardiac complications.

Depression and heart disease have a complicated relationship as major depressive disorder is an independent risk factor for the development of coronary artery disease (CAD) and increases the risk of cardiac events and premature death.

The prevalence of depression among patients requiring cardiac surgery ranges from 23 percent to 47 percent.bigstockphoto_Running__390261

This rate is higher than the rate of depression found among people with general CAD, including those who have had a heart attack, and is nearly twice as common as in the general population without cardiac disease.

Researchers have discovered approximately half of patients suffering from depression before cardiac surgery remain depressed one year after surgery.

Further, an additional 20 percent of patients who undergo a coronary artery bypass procedure experience new or elevated depressive symptoms after surgery.

Moderate to severe depression after cardiac surgery increases the risk of further cardiac complications.

Evidence describing the change in physical activity status before and after cardiac surgery, and whether physical activity status is associated with depressive symptoms following surgery, is limited.

In a new study, investigators from the University of Manitoba sought to define who is at risk for depression after surgery, whether all patients experience similar mood changes, how and when physical activity changes, and how this affects depression after surgery.

They conducted the Impact of Physical Activity on Depression After Cardiac Surgery (IPAD-CS) study to assess 436 patients who were undergoing elective cardiac surgery or awaiting in-hospital cardiac surgery requiring cardiopulmonary bypass in 2010-2011.

Patients were assessed for short-term depression and physical activity behavior before surgery, at hospital discharge, and three and six months after surgery.

Results show that physical inactivity was an independent risk factor for increased depressive symptoms before surgery and that inactive patients had double the risk of experiencing depressive symptoms preoperatively.

Preoperative depression and postoperative stressful events were the strongest associations after surgery.

Physical inactivity was associated with preoperative depression and new depression six months after surgery.

Strikingly, the investigators found that 58 percent of the “at-risk” group progressed to clinical depression after surgery compared to 28 percent in the “naive” group, and that 23 percent remained depressed after six months.

Furthermore, stressful events (e.g., death in family, divorce, living alone) became significantly associated with depression at three and six months after surgery, suggesting that factors predisposing patients with cardiac disease to elevated symptoms of depression are not fixed and vary over time.

A subgroup of patients who were not depressed at baseline, but who became depressed by the three- or six-month follow-up, demonstrated a significant decrease in physical activity from baseline to six-month follow-up compared to those who remained free from depression.

One caveat the investigators point out is whether reduced physical activity increased depressive symptoms or, conversely, if depression resulted in sedentary behavior.

Antidepressant medications remain the mainstay of current depression treatment strategies.

However, their use is controversial in patients with coronary artery disease. Previous studies have shown that exercise as a treatment among patients with coronary artery disease is as effective as antidepressants for reducing depressive symptoms.

However, it is not yet known if physical activity has a similar effect in patients undergoing cardiac surgery who already have depression.

“Depression in the patient undergoing cardiac surgery appears complex,” says lead investigators Rakesh C. Arora, MD, PhD and Todd Duhamel, PhD.

“We have identified that although seven independent factors are associated with depression before and after cardiac surgery, different mood responses in different subsets of patients exist. Furthermore, patients ‘at risk’ for depression represent a new high-risk subset.

Preoperative physical inactivity independently poses a two-fold risk for depression before surgery and is associated with the development of new depression postoperatively.

“These findings justify more detailed assessments of depression and physical activity before, during, and after surgery, and the need for assisted bio-psycho-social support in patients undergoing cardiac surgery,” they conclude.

This article first appeared on ‘Psych Central’ on 20 December 2013.


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